In this #Fem4PeoplesVaccine podcast, we look at how COVID-19 impacted communities in Africa. The pandemic exacerbated existing inequalities that were further deepened by State-led authoritarian approaches to lockdown measures. Marginalised groups, especially women and adolescent girls as well as Indigenous communities in Africa, were disproportionately affected. The podcast moderated by Adija Adamu of the International Indigenous Women’s Forum and the Ayni Fund, with speakers Khoudia Sow and Leah Eryenyu, examines how the disruption of health services and access to health-related services such as HIV testing, resulted in high teen pregnancy rates, and new HIV infections among adolescent girls.