This is an edited version of the trigger paper written by Gita Sen for the Inter-regional Meeting of the Global South Coalition for SRHR and Development Justice, Johannesburg, 1-3 September 2025. Originally intended as an internal document to trigger discussion, it has been edited for a wider audience. It is not comprehensive but selective in its choice of issues. With many thanks to the participants at the Johannesburg meeting, and especially to Laura Laski, Rajat Khosla and Alexa Johns.